mTOR (Mechanistic Target of Rapamycin)

Inflammation: Mast cells, eosinophils, and Th2 immune cells release histamine, leukotrienes, and cytokines that swell the airway tissue.
Bronchoconstriction: The smooth muscles surrounding the airways contract sharply, narrowing airflow passages.
Mucus overproduction: Chronic inflammation triggers excess mucus that further blocks breathing.

Description

A central nutrient-sensing kinase that regulates cell growth, metabolism, and survival. Chronic activation of mTOR promotes cancer progression by enhancing protein synthesis, angiogenesis, and inhibiting autophagy, while its inhibition (e.g., by fasting) supports longevity and metabolic repair.

Diseases affected by this mechanism

Viral Infection