Clostridioides difficile Infection

Description

An intestinal infection caused by Clostridioides difficile bacteria, often occurring after antibiotic use. Causes severe diarrhea and colitis.

Carbohydrate Dependency: Clostridioides difficile is carbohydrate-dependent, using glucose metabolism for growth and toxin production. Weakens significantly during fasting or ketogenic/carnivore diets when glucose is restricted.

Root Causes

Carbohydrate consumption

[ 1 ] Yannick D N Tremblay et al. (2021) DOI PMCID PMID [ 2 ] J Collins et al. (2018) DOI PMCID PMID [ 3 ] Md Zahidul Alam et al. (2024) DOI PMCID PMID

Treatment Options

Fasting

Antibiotics

Susceptibilities

Systemic Inflammation

Sources

[1] Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile

[ 1 ] Yannick D N Tremblay et al. (2021) DOI PMCID PMID

[2] Dietary trehalose enhances virulence of epidemic Clostridium difficile

[ 2 ] J Collins et al. (2018) DOI PMCID PMID

[3] Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis

[ 3 ] Md Zahidul Alam et al. (2024) DOI PMCID PMID