Arthritis

Description

Arthritis refers to inflammation and degeneration of the joints, leading to pain, stiffness, and reduced mobility. It includes both osteoarthritis—caused by wear, metabolic inflammation, and oxidative stress—and autoimmune forms such as rheumatoid arthritis, where the immune system attacks joint tissue. Modern evidence links arthritis to systemic inflammation, insulin resistance, gut permeability, and microbiome dysbiosis, often driven by refined carbohydrate intake and obesity. Chronic oxidative stress and leaky gut allow bacterial toxins and inflammatory cytokines (e.g., IL-1β, TNF-α, IL-6) to damage cartilage and bone over time.

Treatment Options

[ 3 ] Larissa J Strath et al. (2019) DOI PMCID PMID [ 4 ] Kade S. Lyman et al. (2019) DOI PMCID PMID [ 5 ] Jacopo Ciaffi et al. (2024) DOI PMCID PMID [ 6 ] Asia M Wiggins et al. (2024) DOI PMCID PMID
[ 3 ] Larissa J Strath et al. (2019) DOI PMCID PMID [ 4 ] Kade S. Lyman et al. (2019) DOI PMCID PMID [ 5 ] Jacopo Ciaffi et al. (2024) DOI PMCID PMID [ 6 ] Asia M Wiggins et al. (2024) DOI PMCID PMID

Sources

[1] Leaky gut and autoimmune diseases
[ 1 ] Fasano A et al. (2012) DOI PMID
[2] Insulin resistance as a predictor of age-related diseases
[ 2 ] F S Facchini et al. (2001) DOI PMID
[3] The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis
[ 3 ] Larissa J Strath et al. (2019) DOI PMCID PMID
[4] Continuous care intervention with carbohydrate restriction improves physical function of the knees among patients with type 2 diabetes: a non-randomized study
[ 4 ] Kade S. Lyman et al. (2019) DOI PMCID PMID
[5] Efficacy, Safety, and Tolerability of a Very Low-Calorie Ketogenic Diet in Women with Obesity and Symptomatic Knee Osteoarthritis: A Pilot Interventional Study
[ 5 ] Jacopo Ciaffi et al. (2024) DOI PMCID PMID
[6] The effect of a low-carbohydrate diet on evoked pain and quality of life in Non-Hispanic black women with knee osteoarthritis: a pilot study
[ 6 ] Asia M Wiggins et al. (2024) DOI PMCID PMID