Multiple myeloma

Root Causes

[ 1 ] Saeid Doaei et al. (2019) DOI PMID [ 2 ] Anna E Arthur et al. (2018) DOI PMID [ 3 ] Christian A Maino Vieytes et al. (2019) DOI PMID [ 4 ] Jian Huang et al. (2017) DOI PMID [ 5 ] Maria V Liberti et al. (2017) DOI PMID [ 6 ] Takahiko Nakagawa et al. (2020) DOI PMID [ 7 ] Siyuan Xia et al. (2017) DOI PMCID PMID

Insulin Resistance

[ 8 ] F S Facchini et al. (2001) DOI PMID

IGF-1 (Insulin-like Growth Factor 1)

[ 9 ] Pollak M et al. (2004) DOI PMID [ 10 ] Baserga R et al. (2003) DOI PMID [ 11 ] O Larsson et al. (2005) DOI PMID

Systemic Inflammation

[ 12 ] Balkwill F et al. (2001) DOI PMID

mTOR (Mechanistic Target of Rapamycin)

[ 13 ] Robert A. Saxton et al. (2017) DOI PMID [ 14 ] Alejo Efeyan et al. (2010) DOI PMID [ 15 ] David A Fruman et al. (2017) DOI PMID [ 16 ] Panomwat Amornphimoltham et al. (2008) DOI PMID [ 17 ] Ma'anit Shapira et al. (2006) DOI PMID [ 18 ] David T Teachey et al. (2006) DOI PMID

Treatment Options

Fasting

[ 19 ] Lee C et al. (2012) DOI PMID [ 20 ] Sagun Tiwari et al. (2022) DOI PMID [ 21 ] Sebastian Brandhorst et al. (2021) DOI PMID [ 22 ] Maira Di Tano et al. (2020) DOI PMID [ 23 ] Alessio Nencioni et al. (2019) DOI PMID [ 24 ] Yichun Xie et al. (2024) DOI PMID [ 25 ] Albin Sjölin et al. (2022) Link [ 26 ] Stefanie de Groot et al. (2019) DOI PMID [ 27 ] M Mansilla-Polo et al. (2024) DOI PMID [ 28 ] Ciara H O'Flanagan et al. (2017) DOI PMCID PMID

Ketogenic Diet

[ 29 ] Irene Caffa et al. (2020) DOI PMID [ 30 ] Salvatore Cortellino et al. (2023) DOI PMID [ 25 ] Albin Sjölin et al. (2022) Link [ 21 ] Sebastian Brandhorst et al. (2021) DOI PMID [ 31 ] Giulia Salvadori et al. (2021) DOI PMID [ 27 ] M Mansilla-Polo et al. (2024) DOI PMID

Susceptibilities

Autophagy

Sources

[1] Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level

[ 1 ] Saeid Doaei et al. (2019) DOI PMID

[2] Higher carbohydrate intake is associated with increased risk of all-cause and disease-specific mortality in head and neck cancer patients: results from a prospective cohort study

[ 2 ] Anna E Arthur et al. (2018) DOI PMID

[3] Carbohydrate Nutrition and the Risk of Cancer

[ 3 ] Christian A Maino Vieytes et al. (2019) DOI PMID

[4] A meta-analysis between dietary carbohydrate intake and colorectal cancer risk: evidence from 17 observational studies

[ 4 ] Jian Huang et al. (2017) DOI PMID

[5] The Warburg Effect: How Does it Benefit Cancer Cells?

[ 5 ] Maria V Liberti et al. (2017) DOI PMID

[6] Fructose contributes to the Warburg effect for cancer growth

[ 6 ] Takahiko Nakagawa et al. (2020) DOI PMID

[7] Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth

[ 7 ] Siyuan Xia et al. (2017) DOI PMCID PMID

[8] Insulin resistance as a predictor of age-related diseases

[ 8 ] F S Facchini et al. (2001) DOI PMID

[9] Insulin-like growth factor-I and risk of breast cancer by age and hormone receptor status

[ 9 ] Pollak M et al. (2004) DOI PMID

[10] The role of the IGF-I receptor in cancer

[ 10 ] Baserga R et al. (2003) DOI PMID

[11] Role of insulin-like growth factor 1 receptor signalling in cancer

[ 11 ] O Larsson et al. (2005) DOI PMID

[12] Inflammation and cancer: back to Virchow?

[ 12 ] Balkwill F et al. (2001) DOI PMID

[13] mTOR signaling in growth control and disease

[ 13 ] Robert A. Saxton et al. (2017) DOI PMID

[14] mTOR and cancer: many loops in one pathway

[ 14 ] Alejo Efeyan et al. (2010) DOI PMID

[15] The PI3K-AKT-mTOR pathway in human cancer: genetic alterations and therapeutic implications

[ 15 ] David A Fruman et al. (2017) DOI PMID

[16] Inhibition of mTOR by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

[ 16 ] Panomwat Amornphimoltham et al. (2008) DOI PMID

[17] The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

[ 17 ] Ma'anit Shapira et al. (2006) DOI PMID

[18] The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

[ 18 ] David T Teachey et al. (2006) DOI PMID

[19] Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

[ 19 ] Lee C et al. (2012) DOI PMID

[20] Effect of fasting on cancer: A narrative review of scientific evidence

[ 20 ] Sagun Tiwari et al. (2022) DOI PMID

[21] Fasting and fasting-mimicking diets for chemotherapy augmentation

[ 21 ] Sebastian Brandhorst et al. (2021) DOI PMID

[22] Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

[ 22 ] Maira Di Tano et al. (2020) DOI PMID

[23] Fasting and cancer: molecular mechanisms and clinical application

[ 23 ] Alessio Nencioni et al. (2019) DOI PMID

[24] Fasting as an Adjuvant Therapy for Cancer: Mechanism of Action and Clinical Practice

[ 24 ] Yichun Xie et al. (2024) DOI PMID

[25] Cancer whitepaper

[ 25 ] Albin Sjölin et al. (2022) Link

[26] Effects of short-term fasting on cancer treatment

[ 26 ] Stefanie de Groot et al. (2019) DOI PMID

[27] Popular Diets and Skin Effects: A Narrative Review

[ 27 ] M Mansilla-Polo et al. (2024) DOI PMID

[28] When less may be more: calorie restriction and response to cancer therapy

[ 28 ] Ciara H O'Flanagan et al. (2017) DOI PMCID PMID

[29] Fasting-mimicking diet and hormone therapy induce breast cancer regression

[ 29 ] Irene Caffa et al. (2020) DOI PMID

[30] Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects

[ 30 ] Salvatore Cortellino et al. (2023) DOI PMID

[31] Intermittent and Periodic Fasting, Hormones, and Cancer Prevention

[ 31 ] Giulia Salvadori et al. (2021) DOI PMID